Wan-Ling Chen Selected Research

Trehalase

1/2020	Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability.
1/2016	Novel Lactulose and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models of Spinocerebellar Ataxia 3.
5/2015	The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment.

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Wan-Ling Chen Research Topics

Disease

13	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 11/2020 - 01/2013
6	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 01/2013
4	Parkinson Disease (Parkinson's Disease) 01/2021 - 01/2013
4	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 01/2019 - 01/2013
3	Huntington Disease (Huntington's Disease) 01/2016 - 01/2013
2	Inflammation (Inflammations) 01/2021 - 11/2020
2	Neuroinflammatory Diseases 01/2021 - 11/2020
1	Gram-Negative Bacterial Infections 01/2021
1	Salmonella Infections (Salmonellosis) 01/2021
1	Bacteremia 01/2021
1	Squamous Cell Carcinoma of Head and Neck 02/2020
1	Neuritis (Polyneuritis) 01/2020
1	Hepatitis 02/2019
1	Ataxia (Dyssynergia) 01/2019
1	Wounds and Injuries (Trauma) 01/2019
1	Respiratory Insufficiency (Respiratory Failure) 01/2018
1	Transfusion Reaction 11/2017
1	Leukemia 10/2017
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2017
1	Parkinsonian Disorders (Parkinsonism) 11/2016
1	Urinary Tract Infections (Urinary Tract Infection) 01/2016
1	Fever (Fevers) 01/2016
1	Tauopathies 01/2016
1	Vomiting 06/2015
1	Nausea 06/2015
1	Atrophy 06/2014
1	Mitochondrial Diseases (Mitochondrial Disease) 06/2014
1	Infections 08/2010
1	Colorectal Neoplasms (Colorectal Cancer) 02/2009
1	Hemorrhage 11/2008
1	Brain Ischemia (Cerebral Ischemia) 11/2008
1	Brain Infarction 11/2008
1	Ischemic Stroke 11/2008
1	Brain Edema (Cerebral Edema) 11/2008
1	Schizophrenia (Dementia Praecox) 01/2007

Drug/Important Bio-Agent (IBA)

12	polyglutamineIBA 11/2020 - 01/2013
6	Proteins (Proteins, Gene)FDA Link 01/2020 - 02/2009
4	tributyl phosphate (TBP)IBA 01/2020 - 01/2014
4	TATA-Box Binding Protein (TATA-Binding Protein)IBA 01/2020 - 01/2014
3	Lactulose (Duphalac)FDA LinkGeneric 01/2020 - 05/2015
3	MelibioseIBA 01/2020 - 05/2015
3	TrehalaseIBA 01/2020 - 05/2015
2	Pharmaceutical PreparationsIBA 01/2021 - 05/2015
2	SynucleinsIBA 01/2021 - 01/2020
2	TrehaloseIBA 01/2016 - 05/2015
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2021
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2021
1	Interleukin-6 (Interleukin 6)IBA 01/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021
1	InterferonsIBA 01/2021
1	Colistin (Coly-Mycin)FDA Link 01/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2021
1	AntioxidantsIBA 11/2020
1	AutoantibodiesIBA 02/2020
1	Peptide Initiation Factors (Initiation Factor)IBA 01/2020
1	glycyrrhizae radix et rhizomaIBA 01/2019
1	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2019
1	UbiquitinIBA 01/2019
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2019
1	Human Platelet AntigensIBA 11/2017
1	NF-kappa B (NF-kB)IBA 10/2017
1	F-Box ProteinsIBA 11/2016
1	CreatinineIBA 01/2016
1	beta-Lactamases (beta-Lactamase)IBA 01/2016
1	C-Reactive ProteinIBA 06/2015
1	DisaccharidesIBA 05/2015
1	indoleIBA 10/2014
1	Mutant Proteins (Protein, Mutant)IBA 06/2014
1	peoniflorinIBA 01/2013
1	Phosphotransferases (Kinase)IBA 01/2013
1	Leucine (L-Leucine)FDA Link 01/2013
1	Oxacillin (Prostaphlin)FDA LinkGeneric 08/2010
1	Glutathione (Reduced Glutathione)IBA 02/2009
1	MelatoninIBA 11/2008
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 11/2008
1	Matrix Metalloproteinases (MMPs)IBA 11/2008

Therapy/Procedure

4	Therapeutics 01/2021 - 02/2019
1	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2019
1	Artificial Respiration (Mechanical Ventilation) 01/2018
1	Thrombolytic Therapy 11/2008
1	Activities of Daily Living (ADL) 01/2007
1	Occupational Therapy (Therapy, Occupational) 01/2007